The objective of present work was to develop the matrix tablets of capcitabine using natural polymers, guar gum and xanthan gum, for colon specific drug delivery and sustained release. The tablets were prepared by wet granulation technique which will provide the sustained release of the drug; various concentrations of the polymer were used to optimize the formulation. The influence of buffer pH and drug/polymer ratio on the drug release was studied. The in-vitro drug release studies were performed in HCl buffer pH 1.2 and Phosphate buffer pH 7.4. Relatively slow release of drug was seen from formulation having matrices containing optimum concentration of xanthan gum and guar gum. Accelerated stability studies were also carried out following ICH Guidelines. The results of 32 factorial full factorial designs shown that the polymer: drug ratio and type of polymer affects the rate of drug release.
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